Status:
COMPLETED
Asymptomatic Versus Symptomatic Mild COPD: Comparisons at Rest and at Exercise
Lead Sponsor:
Centre Hospitalier Universitaire de Besancon
Conditions:
Chronic Obstructive Pulmonary Disease
Eligibility:
All Genders
40+ years
Phase:
NA
Brief Summary
The current definition of chronic obstructive pulmonary disease (COPD) is based on the presence of persistent airflow obstruction assessed by spirometry. About half of the subjects with mild COPD (i.e...
Detailed Description
Subjects attend one single visit. If needed, COPD subjects are asked to stop any respiratory related medication such as short and long acting bronchodilators 72 hours prior to the visit. Subjects are ...
Eligibility Criteria
Inclusion
- For COPD groups: post-bronchodilator forced expiratory volume in 1 sec (FEV1) ≥ 80% predicted and a FEV1/forced vital capacity (FVC) ratio \< 0.70
- For the "Asymptomatic mild COPD" group: modified Medical Research Council (mMRC) score equal to zero and absence of respiratory symptoms including chronic cough and/or chronic expectoration and/or chronic wheeze.
- For the "Symptomatic mild COPD" group: mMRC) score \> 0
- For the "Healthy controls" group: FEV1 \> 80% predicted and FEV1/FVC \> 0.7) and a mMRC score equal to zero and absence of respiratory symptoms including chronic cough and/or chronic expectoration and/or chronic wheeze
- Able to perform all study procedures and provide informed consent
Exclusion
- Presence of a medical condition other than COPD that could cause or contribute to breathlessness (i.e., a respiratory disease other than COPD and/or a metabolic and/or a cardiovascular disease)
- Presence of disorders other than COPD that could interfere with exercise testing, such as neuromuscular diseases or musculoskeletal problems
- History or clinical evidence of asthma
- Use of daytime oxygen or exercise-induced arterial oxygen desaturation to \<80% on room air
Key Trial Info
Start Date :
September 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2014
Estimated Enrollment :
111 Patients enrolled
Trial Details
Trial ID
NCT02235025
Start Date
September 1 2012
End Date
May 1 2014
Last Update
September 9 2014
Active Locations (1)
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1
Department of respiratory diseases
Besançon, France, 25000