Status:
COMPLETED
Comparison of Treatments Following Total Knee Replacement
Lead Sponsor:
University of Pittsburgh
Collaborating Sponsors:
Patient-Centered Outcomes Research Institute
Conditions:
Degeneration; Articular Cartilage, Knee
Rheumatoid Arthritis
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Although total knee replacement (TKR) improves pain in numerous patients, it does not resolve many of the substantial functional limitations and physical inactivity that existed for a long time prior ...
Detailed Description
This is a comparative effectiveness study, designed as a 3-group single-blind randomized clinical trial. Two hundred forty older adults who underwent TKR at least 2 months prior and are otherwise elig...
Eligibility Criteria
Inclusion
- Unilateral TKR 2 to 4 months prior
- Older than 60 years of age
- Experience functional limitation in daily activities (score in WOMAC-PF of at least 9 points)
- Speak sufficient English to understand study instructions
- Have medical clearance to participate in the study
- Are willing to be randomized to one of the 3 treatment arms
Exclusion
- Have absolute or relative contraindications to exercise
- Have history of uncontrolled cardiovascular disease or hypertension
- Are unable to walk 50 meters without an assistive device
- Have history of muscular or neurological disorder that affect lower extremity function
- Regular participation in exercise
- Terminal illness
- Planning to have another joint replacement during the next 12 months
- Plan not to be around during the next 12 months
Key Trial Info
Start Date :
December 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 7 2017
Estimated Enrollment :
240 Patients enrolled
Trial Details
Trial ID
NCT02237911
Start Date
December 1 2014
End Date
September 7 2017
Last Update
March 11 2019
Active Locations (1)
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1
Department of Physical Therapy, University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15219