Status:
WITHDRAWN
Study of High Dosage of Losartan in Comparison to Low Dose of Losartan in Heart Failure Patients
Lead Sponsor:
Baker Heart and Diabetes Institute
Conditions:
Heart Failure
Eligibility:
All Genders
21-75 years
Phase:
PHASE4
Brief Summary
The sympathetic nervous system, a part of the nervous system that stimulates the heart via release of substances, noradrenaline and adrenaline (combined called catecholamines), becomes activated in pe...
Eligibility Criteria
Inclusion
- Males and females age between 21 and 75 years
- Diagnosis of mild to moderate congestive heart failure
- Coronary angiography identifying coronary artery disease as the likely cause of congestive heart failure
- Left Ventricular (LV) ejection fraction between 20 to 40 percent on echocardiography or RNA
- Sinus rhythm
Exclusion
- Insulin-dependent diabetes mellitus
- Hypertension (higher than 140/90 mmHg at rest)
- Use of sympatholytic agents such as clonidine, methyldopa, reserpine
- Significant non-cardiac disease, possibly affecting cardiovascular regulation
- Autonomic neuropathy of any cause
- Leg injuries with nerve damage
- Poor bladder control
- Recent history of alcoholism, drug abuse, significant psychiatric disorders
- Known adverse events to AT1-receptor blockers
- Unlikely to tolerate being off digoxin and off blockers of the RAS for a short period
- Ischemic event within past 3 months
- Serum creatinine higher than 200 mmol/L
- Patients taking digoxin for atrial fibrillation
- Patients who require treatment with aldactone
- Patients with more than mild stable angina while on beta-blockers and/or calcium antagonists
- Patients on coumadin
Key Trial Info
Start Date :
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02238457
Last Update
November 2 2018
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.