Status:
COMPLETED
Topiramate-Phentermine Combinations for Cocaine Dependence
Lead Sponsor:
University of Kentucky
Collaborating Sponsors:
National Institute on Drug Abuse (NIDA)
Conditions:
Cocaine Use Disorder
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
This study will determine the influence of topiramate (Topamax®) and phentermine (Adipex®), alone and in combination, on the reinforcing, subjective and physiological effects of cocaine.
Eligibility Criteria
Inclusion
- Recent cocaine use by the intranasal or intravenous route
Exclusion
- Abnormal screening outcome (e.g., ECG, blood chemistry result) that study physicians deem clinically significant
- Current or past histories of substance abuse or dependence that are deemed by the study physicians to interfere with study completion
- History of serious physical disease, current physical disease, impaired cardiovascular functioning, chronic obstructive pulmonary disease, history of seizure or current or past histories of serious psychiatric disorder that in the opinion of the study physician would interfere with study participation will be excluded from participation
- Females not currently using effective birth control
- Contraindications to cocaine, topiramate or phentermine
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2019
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT02239913
Start Date
September 1 2014
End Date
September 1 2019
Last Update
November 27 2019
Active Locations (1)
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1
University of Kentucky Medical Center
Lexington, Kentucky, United States, 40536