Status:
TERMINATED
Confocal Laser Endomicroscopy for Brain Tumors
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
Low Grade Glioma (LGG), High Grade Glioma (HGG)
Eligibility:
All Genders
18+ years
Phase:
PHASE1
Brief Summary
Confocal Laser Endomicroscopy (CLE) could be a useful tool for real-time diagnosis of brain lesions (initial diagnosis or follow-up post resection to check for residual dysplasia) and real-time assess...
Eligibility Criteria
Inclusion
- Patients older than 18 years old
- Clinical signs and history of the disease in favor of a HGG, LGG
- MRI study in favor of a HGG, LGG, meningioma or brain metastasis
- Affiliated to or beneficiary of a social security system (or equivalent).
- Patients who have provided written informed consent for the study
Exclusion
- \- Allergy to fluorescein
- Previous life-threatening allergic reactions and known hypersensitivity
- Pregnant or lactating or not using effective contraception;
- Restricted renal function define by a creatinine clearance \< 30ml/min
- Patients under a beta-blockers treatment
- Contraindication to do an MRI (pace-maker)
- Contraindication to the use of 5-ALA : known hypersensibility to 5-ALA or to porphyrin, acute or chronic porphyria
- Minor or adult ward of court (under guardianship or trusteeship)
- No affiliation to a social security system (or equivalent).
- Patients who express opposition to participation in the study.
Key Trial Info
Start Date :
September 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02240758
Start Date
September 1 2014
End Date
January 1 2015
Last Update
November 26 2015
Active Locations (1)
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1
Hospices Civils de Lyon
Lyon, France