Status:
COMPLETED
Preoperative Ketamine Has no Preemptive Analgesic Effect in Patients Undergoing Colon Surgery.
Lead Sponsor:
Hospital Arquitecto Marcide
Collaborating Sponsors:
Complexo Hospitalario Universitario de A Coruña
Conditions:
Pain, Postoperative
Eligibility:
All Genders
18-75 years
Phase:
PHASE4
Brief Summary
The analgesic properties of ketamine are associated with its non-competitive antagonism of the N-methyl-D-aspartate receptor; these receptors exhibit an excitatory function on pain transmission and th...
Detailed Description
In spite of the techniques we have at our disposal and the elementary nature of incisional pain, optimal pain management remains a challenge. Because the severity of early postoperative pain relates t...
Eligibility Criteria
Inclusion
- age between 18 and 75 years
- normal Body Mass Index (18.5 - 24.9)
- American Society of Anesthesiologists (ASA) class I, II or III
- elective surgery
- surgery time between 60-150 min
- understanding of the Visual Analog Scale (VAS)
- lack of allergies or intolerance to anesthetics
- absence of psychiatric illness
Exclusion
- cognitive deterioration
- inability to use the Patient-Controlled-Analgesia (PCA) device
- history of chronic pain syndromes
- chronic use of analgesics, sedatives, opioids or steroids
- liver or hematologic disease,
- history of drug or alcohol abuse
- intolerance to ketamine or Paracetamol.
Key Trial Info
Start Date :
September 1 2001
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 1 2002
Estimated Enrollment :
48 Patients enrolled
Trial Details
Trial ID
NCT02241278
Start Date
September 1 2001
End Date
June 1 2002
Last Update
September 16 2014
Active Locations (1)
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1
Hospital Arquitecto Marcide
Ferrol, A Coruna, Spain, 15405