Status:
COMPLETED
Insulin Resistance and Reward
Lead Sponsor:
VA Office of Research and Development
Collaborating Sponsors:
Washington University School of Medicine
Conditions:
Obesity
Eligibility:
All Genders
25-60 years
Phase:
PHASE2
Brief Summary
Obesity is a common problem in the Veteran population as at least 1 in 3 Veterans are obese. When obese people eat food they have less response in areas of the brain that sense pleasure (reward). Decr...
Detailed Description
The current research proposal will investigate the relationship of insulin sensitivity to brain reward signaling. In most obese individuals, insulin signaling is impaired (insulin resistance). Preclin...
Eligibility Criteria
Inclusion
- Age 25-60yoa, inclusive.
- BMI 30.0 and 45.0 kg/m2, inclusive.
- Normal visual acuity with correction.
- Able to travel regularly to the St. Louis VA and Washington University for research visits.
- Completed signed informed consent form.
Exclusion
- Current or history of significant psychiatric disease, including Binge Eating Disorder (BED).
- Current or history of significant substance abuse or extended use of tobacco.
- Contraindications for MRI (e.g., pregnancy, claustrophobia, pacemaker, circumference \> 54 inches, weight \> 400 lbs, etc.);
- Significant cardiovascular, pulmonary, renal, liver, neurologic, or metabolic disease.
- Diabetes mellitus.
- Significant anemia.
- Treatment with a medication the affects insulin sensitivity.
- Treatment with centrally acting medications.
- Frequent shift work.
- Significant in-mobility or unable to lay on back still for 1 hour.
- History of bariatric surgery.
- Food allergies/ intolerance that would prevent completing study.
- Symptoms concerning for untreated active mental health disease
Key Trial Info
Start Date :
November 17 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2020
Estimated Enrollment :
59 Patients enrolled
Trial Details
Trial ID
NCT02241603
Start Date
November 17 2014
End Date
July 1 2020
Last Update
July 8 2020
Active Locations (1)
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1
St. Louis VA Medical Center John Cochran Division, St. Louis, MO
St Louis, Missouri, United States, 63106