Status:
COMPLETED
Investigating the Influence of Semaglutide on the Pharmacokinetics of Single Doses of Atorvastatin and Digoxin in Healthy Subjects
Lead Sponsor:
Novo Nordisk A/S
Conditions:
Diabetes
Healthy
Eligibility:
All Genders
18-55 years
Phase:
PHASE1
Brief Summary
The trial is conducted in Europe. The aim of the trial is to investigate the influence of semaglutide on the pharmacokinetics (the exposure of the trial drug in the body) of single doses of atorvastat...
Eligibility Criteria
Inclusion
- Male and female, age between 18 and 55 years (both inclusive) at the time of signing informed consent
- Body mass index between 20.0 and 29.9 kg/m\^2 (both inclusive)
Exclusion
- Female who is pregnant, breast-feeding or intends to become pregnant or is of child-bearing potential and not using an adequate contraceptive method. Women of child-bearing potential must use an effective method of birth control throughout the trial including the 5 weeks follow-up period. Only highly effective methods of birth control are accepted (i.e. one that results in less than 1% per year failure rate when used consistently and correctly such as implants, injectables, combined oral contraceptives, some intrauterine device), or sexual abstinence or vasectomised partner
- Any clinically significant disease history, in the opinion of the investigator, or systemic or organ disease including: cardiac, pulmonary, gastrointestinal, hepatic, neurologic, renal, genitourinary and endocrine, dermatologic or hematologic diseases
- Use of prescription or non-prescription systemic or topical medicinal products (including routine or non-routine vitamins or herbal supplements, but excluding paracetamol and contraceptives) within 3 weeks (or within 5 half-lives of the medicinal product, whichever is longest) prior to Visit 2 (first dose administration)
- History of drug/chemical substance abuse within 1 year from screening, or a positive result in the urine drug test
- History of alcohol abuse within 1 year from screening, or a positive result in the alcohol urine test, or consumption of more than 21 units (male)/14 units (female) of alcohol weekly (one unit of alcohol equals about 250 mL of beer or lager, one glass (120 mL) of wine, or 20 mL spirits)
- Smoking in the last 3 months prior to screening or a positive nicotine test
Key Trial Info
Start Date :
September 16 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 7 2015
Estimated Enrollment :
31 Patients enrolled
Trial Details
Trial ID
NCT02243098
Start Date
September 16 2014
End Date
April 7 2015
Last Update
April 4 2017
Active Locations (1)
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1
Novo Nordisk Investigational Site
Berlin, Germany, 14050