Status:
COMPLETED
Effects of a PUFA-rich Diet on Acute Metabolic and Inflammatory High-Fat Meal Responses
Lead Sponsor:
University of Georgia
Conditions:
Inflammation
Obesity
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
This study evaluates whether a diet rich in poly-unsaturated fats can compensate for the negative effects of high saturated fat meals on metabolic, inflammatory, and coagulation responses. Half of the...
Detailed Description
Eating more saturated fats has been shown to decrease how many calories an individual burns and increase chronic disease risk by increasing inflammation, coagulation (blood clotting) potential, blood ...
Eligibility Criteria
Inclusion
- Apparently healthy men and women between the ages of 18 and 45y with a normal weight based on body mass index (BMI=18-24.9kg/m2), must be sedentary (perform less than 3 hours per week of structured exercise) and , if participant has fasting total cholesterol \>200 gm/dL, high-density lipoprotein \<40 mg/dL, low-density lipoprotein cholesterol \>100 mg/dL, and/or triglycerides \>150 mg/dL (based on fasting blood lipids).
Exclusion
- Weight loss or gain exceeding 5% of body weight in the past 3 months
- Current participation in a weight loss program
- Any current exercisers (greater than 3h per week)
- Any person who is on a medically prescribed diet
- Any person who is vegan, or any type of vegetarian other than pesco-vegetarian
- Any chronic or metabolic disease, hyperlipidemia, gastrointestinal disorder, or history of medical or surgical events that could affect digestion and absorption of nutrients
- Any current supplement use other than a daily multivitamin (this includes fish oil supplements)
- Any current medication use other than birth control (this includes anti-inflammatory NSAID use).
- Anyone who is pregnant, lactating, or planning a pregnancy
- Anyone who has donated blood or plasma in the last 20 days
- Any tobacco users
- Anyone who has allergies to the most common food allergens (milk, eggs, peanuts, almonds, cashews, walnuts, fish, shellfish, soy and wheat) or to any of the food that will provided during the study
- Anyone who has allergies to any of the components of the liquid meals
Key Trial Info
Start Date :
September 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT02246933
Start Date
September 1 2013
End Date
August 1 2015
Last Update
October 8 2015
Active Locations (1)
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1
University of Georgia - Department of Foods and Nutrition
Athens, Georgia, United States, 30602