Status:
COMPLETED
Cholinesterase Inhibitor Discontinuation
Lead Sponsor:
VA Office of Research and Development
Conditions:
Dementia
Eligibility:
All Genders
60+ years
Phase:
PHASE2
PHASE3
Brief Summary
This study tries to determine if stopping certain medications that are used to treat dementia will cause worsening from the patient and family perspective. All of the participants will take pills tha...
Detailed Description
There are no reliable findings from controlled trials about discontinuation of cholinesterase inhibitors from a patient and family perspective. It is unknown at what point these medications do not hav...
Eligibility Criteria
Inclusion
- Males and females ages 60 and older.
- Taking stable dose of donepezil 10mg or greater per day, or galantamine 8mg or greater per day, for at least 1 year.
- Presence of a primary caregiver who can assume responsibility for medication compliance, OR residence in a nursing home with a staff member who can provide information.
- Primary care visit within last 12 months.
- Willing to have the CI medication discontinued.
Exclusion
- Terminal medical condition for which life expectancy would be less than 6 months.
- Parkinson's Disease
- Presence of any uncontrolled systemic illness that would interfere with participation in the study.
- Unstable medical condition.
- Receiving services from hospice.
- Current prescription with more than one CI
- Receiving medication in an investigational drug study.
Key Trial Info
Start Date :
January 22 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2019
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT02248636
Start Date
January 22 2015
End Date
October 1 2019
Last Update
October 23 2020
Active Locations (4)
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1
Central Arkansas VHS John L. McClellan Memorial Veterans Hospital, Little Rock, AR
Little Rock, Arkansas, United States, 72205-5484
2
Boise VA Medical Center, Boise, ID
Boise, Idaho, United States, 83702
3
Edith Nourse Rogers Memorial Veterans Hospital, Bedford, MA
Bedford, Massachusetts, United States, 01730
4
VA Puget Sound Health Care System Seattle Division, Seattle, WA
Seattle, Washington, United States, 98108