Status:
TERMINATED
Ultra-protective Pulmonary Ventilation Supported by Low Flow ECCO2R for Severe ARDS
Lead Sponsor:
National University Health System, Singapore
Collaborating Sponsors:
Baxter Healthcare Corporation
Conditions:
Respiratory Distress Syndrome, Adult
Eligibility:
All Genders
21-90 years
Phase:
NA
Brief Summary
This study evaluates the use of ultra-protective ventilation, where very low ventilation volumes are used, in patients with severe acute respiratory distress syndrome (ARDS) meeting criteria to nurse ...
Detailed Description
Current best practices for management of severe ARDS include lung protective ventilation and nursing in the prone position. However, the best lung protective strategy is not currently established and ...
Eligibility Criteria
Inclusion
- Admitted to MICU with respiratory failure and intubated
- ARDS criteria per Berlin definition
- PaO2:FiO2 ratio ≤ 200 mmHg for \> 6 hours with FiO2 ≥0.5
- Expected to require mechanical ventilation for \>48 hours
- Reversible disease
Exclusion
- Anticoagulation contraindicated
- Proven HIT
- Unable to obtain central venous access
- Refractory hypoxia (PaO2:FiO2 ≤80 after recruitment and proning) or other indication for ECMO
- Home oxygen use
- Severe COPD
- Interstitial lung disease
- \> 7 days of mechanical ventilation
- Immunocompromised patient (bone marrow, untreated HIV, PJP)
- Advanced malignancy with life expectancy ≤ 6months
Key Trial Info
Start Date :
May 22 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 31 2019
Estimated Enrollment :
8 Patients enrolled
Trial Details
Trial ID
NCT02252094
Start Date
May 22 2017
End Date
May 31 2019
Last Update
September 14 2020
Active Locations (2)
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1
National University Hospital
Singapore, Singapore, 119074
2
Ng Teng Fong General Hospital
Singapore, Singapore, 609606