Status:
COMPLETED
Fluctuation of Airway Function in Children With Asthma
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
Royal Brompton & Harefield NHS Foundation Trust
Swiss National Science Foundation
Conditions:
Asthma
Eligibility:
All Genders
5-17 years
Brief Summary
It is increasingly recognised that asthma is not a single disease but that there are many different phenotypes. Much of the work that we have previously carried out has focussed on differentiating chi...
Detailed Description
Many children present with poorly controlled asthma despite high intensity treatment including high doses of inhaled steroids. A number of these children will get better once the basics of asthma mana...
Eligibility Criteria
Inclusion
- Parent / guardian must be able to give written informed consent prior to participation in the study, which includes ability to comply with the requirements and restrictions listed in the consent form. Informed consent must be obtained prior to undertaking any study procedures.
- Assent should be obtained from all children in the study where appropriate.
- Male or female subject aged between 5 - 17 years inclusive at screening.
- The parent / guardian, or where appropriate the child must be able to read, comprehend, and write at a sufficient level to complete study related materials.
Exclusion
- As a result of medical interview, physical examination or screening investigation the physician responsible considers the child unfit for the study.
- Those who, in the opinion of the investigator, have a risk of non-compliance with study procedures.
- Significant alternative diagnoses that may mimic or complicate asthma, in particular dysfunctional breathing, panic attacks, and overt psychosocial problems (if these are thought to be the major problem rather than in addition to severe asthma)
- Significant other primary pulmonary disorders in particular cystic fibrosis, interstitial lung disease
- Participants with bronchiectasis should only be excluded if this is thought to be the major pulmonary disorder rather than in addition to severe asthma
Key Trial Info
Start Date :
September 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT02252289
Start Date
September 1 2014
End Date
August 1 2015
Last Update
February 22 2016
Active Locations (1)
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1
Royal Brompton Hospital
London, United Kingdom, SW36NP