Status:
COMPLETED
The Effects of Resveratrol and Acute Exercise on Endothelial Function in Postmenopausal Women
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
National Heart, Lung, and Blood Institute (NHLBI)
Conditions:
Endothelial Dysfunction
Eligibility:
FEMALE
50-70 years
Phase:
NA
Brief Summary
This pilot study plans to learn more about the aging of blood vessels and arteries in women. As women age and go through menopause, their risk for cardiovascular disease increases. Also with aging and...
Eligibility Criteria
Inclusion
- Between the ages of 50-70 and at least 1 year beyond menopause;
- resting blood pressure \<140/90 mmHg;
- plasma glucose concentrations \<110 mg/dL under fasting conditions;
- BMI \< 35;
- LDL cholesterol \< 160 mg/dL;
- sedentary or recreationally active (\<3 days of vigorous aerobic exercise);
- no use of OCs, HT, or other medications that might influence cardiovascular function;
- nonsmokers;
- no use of vitamin supplements, blood thinners or NSAIDS, or willing to stop use one month prior to and for the duration of the study;
- not taking any other medications that would interact with E2 patch or resveratrol to confound interpretation of results.
Exclusion
- history of or active E2-dependent neoplasms, acute liver or gallbladder disease, vaginal bleeding, venous thromboembolism, hypertriglyceridemia (≥ 150 mg/dL), and CVD;
- known allergy to transdermal patch, or resveratrol;
- history of stomach ulcer or bleeding;
- other contraindications to HT or resveratrol.
- other conditions for which individuals will be excluded from the study include: diabetes, active infection, history of seizures or disease that affects the nervous system or an abnormal resting ECG.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 25 2016
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT02256540
Start Date
August 1 2014
End Date
March 25 2016
Last Update
March 20 2020
Active Locations (1)
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1
University of Colorado Anschutz Medical Campus
Aurora, Colorado, United States, 80045