Status:
COMPLETED
Extended Out-of-hospital Low-molecular-weight Heparin Prophylaxis Against DVT and PE in Patients Undergoing Major Lung Resection
Lead Sponsor:
McMaster University
Collaborating Sponsors:
Toronto General Hospital
Heart and Stroke Foundation of Canada
Conditions:
Venous Thrombosis
Pulmonary Embolism
Eligibility:
All Genders
18+ years
Brief Summary
Postoperative venous thromboembolism (VTE) is a significant health-care problem, resulting in significant morbidity, mortality and resource utilization. The true incidence is unknown, and may range fr...
Detailed Description
Postoperative venous thromboembolism (VTE) is a significant health-care problem, resulting in significant morbidity, mortality and resource utilization. The true incidence is unknown, and may range fr...
Eligibility Criteria
Inclusion
- Patient Inclusion Criteria
- At least 18 years of age
- Either gender
- Diagnosed with resectable lung cancer or metastatic lung disease eligible to complete metastasectomy
- Undergoing one of the following surgeries: Segmentectomy, wedge resection, lobectomy, bilobectomy or pneumonectomy
- Competent to understand and sign consent documents
- Patient Exclusion Criteria
- Known allergic or anaphylactic reaction to contrast dye, heparin or low molecular weight heparin (LMWH)
- Under current anticoagulation for venous thromboembolism or other medical conditions
- Known renal impairment, defined as creatinine clearance value of less than 55ml/min/m2 as calculated by the Cockroft-Gault method
- History of, or ongoing liver disease, manifested as ascites or previous peritoneal tapping for ascites
- Pregnant or planning to become pregnant
- Diagnosed or treated for VTE in the past 3 months prior to surgery
- Present or previous increase risk of haemorrhage
- History of previous HIT (heparin induced thrombocytopenia)
- Platelet count must be below 75,000
- Previously inserted Inferior Vena Cava Filter (IVC) filter.
Exclusion
Key Trial Info
Start Date :
January 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT02258958
Start Date
January 1 2014
End Date
December 1 2014
Last Update
December 18 2014
Active Locations (2)
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1
St. Joseph's Healthcare Hamilton
Hamilton, Ontario, Canada, L8N 4A6
2
Toronto General Hospital (UHN)
Toronto, Ontario, Canada, M5G 2C4