Status:
COMPLETED
Hepcidin Levels in Sickle Cell Disease (SCD)
Lead Sponsor:
Kenneth Ataga, MD
Collaborating Sponsors:
Augusta University
Conditions:
Sickle Cell Anemia
Sickle - Beta Thalassemia
Eligibility:
All Genders
18-70 years
Brief Summary
The investigators propose that patients with HbSβ-thalassemia have lower levels of hepcidin and higher levels of GDF-15 than HbSS patients during the non-crisis, "steady states." In addition, the inve...
Detailed Description
Sickle cell disease (SCD) refers to a group of inherited disorders characterized by the presence of sickle hemoglobin (HbS) that are associated with episodes of acute illness and progressive organ dam...
Eligibility Criteria
Inclusion
- age 18 - 70 years
- confirmed diagnosis of HbSS or HbS-β thalassemia
- no history of acute vaso-occlusive event (acute pain crisis or acute chest syndrome) requiring emergency room visit or hospitalization over the preceding 4 weeks
- clinically acceptable physical examination and vital signs
- ability of patient or legal representative to understand the requirements of the study and willingness to sign the Informed Consent document.
Exclusion
- pregnancy or breastfeeding
- current acute illness, including a painful crisis
- iron deficiency anemia
- history of liver disease with alanine aminotransferase (ALT) ≥ 3 X upper limit of normal (ULN)
- history of hereditary hemochromatosis, connective tissues disease, chronic inflammatory, disorder, or malignancy
- chronic transfusion program or any transfusion within the previous 3 months
Key Trial Info
Start Date :
March 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
September 1 2015
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT02258997
Start Date
March 1 2014
End Date
September 1 2015
Last Update
October 8 2015
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.