Status:
TERMINATED
Radiation Induced Cardiopulmonary Injury in Humans
Lead Sponsor:
UNC Lineberger Comprehensive Cancer Center
Conditions:
Thoracic
Pulmonary Injury
Eligibility:
All Genders
18+ years
Brief Summary
The purpose of the study is to assess the time, dose dependence, and fraction-size dependence of radiation (RT)-induced changes in regional lung and heart perfusion/function/structure following thorac...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Patients who are to receive 3D-planned RT for tumor within and around the thorax.
- Patients receiving incidental RT to portions of the heart are eligible.
- Estimated minimum expected life expectancy of one year
- Able to undergo the required study-related tests for regional lung injury and regional heart injury
- Patients of child bearing potential age must have a negative pregnancy test and must agree to use appropriate birth control measures while in the study.
- Patients must be able to give informed consent. Informed consent will be obtained prior to enrollment.
Exclusion
- Patients who are anticipated to have thoracic surgery post-RT are ineligible.
- Patients with large mediastinal/hilar tumors compressing the airways/vessels, and negatively impacting on cardiovascular function
- Pregnant or nursing women.
Key Trial Info
Start Date :
June 1 2008
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
Estimated Enrollment :
91 Patients enrolled
Trial Details
Trial ID
NCT02259452
Start Date
June 1 2008
Last Update
February 26 2020
Active Locations (1)
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1
University of North Carolina at Chapel Hill, Department of Radiation Oncology
Chapel Hill, North Carolina, United States, 27599