Status:
COMPLETED
Neuromuscular Blockade for Post-Cardiac Arrest Care
Lead Sponsor:
Beth Israel Deaconess Medical Center
Collaborating Sponsors:
University of Pittsburgh Medical Center
Brigham and Women's Hospital
Conditions:
Cardiac Arrest
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The main purpose of this study is to evaluate if neuromuscular blockade improves lactate clearance (and preliminary secondary clinical outcome measures) as compared to usual care in post-cardiac arres...
Detailed Description
Out-of-hospital cardiac arrest (OHCA) occurs in more than 300,000 patients in the United States each year with an estimated mortality of greater than 90%. Unfortunately, we currently have little to of...
Eligibility Criteria
Inclusion
- Adult (≥ 18 years)
- Cardiac arrest with sustained return of spontaneous circulation (ROSC)
- Comatose (i.e., not following commands) following ROSC
- Undergoing targeted temperature management (TTM)
- Time of enrollment ≤ 6 hours from initiation of targeted temperature management
- Serum Lactate ≥2
Exclusion
- Pre-existing dementia, severe brain injury, or dependence on others for activities of daily living (i.e. a modified Rankin scale (mRS) score of 4 or higher)
- Traumatic etiology of the cardiac arrest
- Protected population (pregnant, prisoner)
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 29 2019
Estimated Enrollment :
83 Patients enrolled
Trial Details
Trial ID
NCT02260258
Start Date
October 1 2014
End Date
May 29 2019
Last Update
January 29 2021
Active Locations (5)
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1
Michael Kurz
Birmingham, Alabama, United States, 35294
2
Beth Israel Deaconess Medical Center
Boston, Massachusetts, United States, 02215
3
Brigham and Women's Hospital
Boston, Massachusetts, United States, 02215
4
Robert Swor
Royal Oak, Michigan, United States, 48073