Status:
COMPLETED
Dexmedetomidine and Delirium in Patients After Cardiac Surgery
Lead Sponsor:
Peking University First Hospital
Collaborating Sponsors:
Chinese Academy of Medical Sciences, Fuwai Hospital
Conditions:
Delirium
C.Surgical Procedure; Cardiac
Eligibility:
All Genders
60-90 years
Phase:
PHASE4
Brief Summary
Postoperative delirium (POD) is a frequently occurring complication after cardiac surgery. Its occurrence is associated with worse outcomes of patients, including increased morbidity, prolonged hospit...
Detailed Description
Delirium is a state of global cerebral dysfunction manifested by acute disturbance of consciousness, attention, cognition and perception. It develops over a short period of time (usually hours to days...
Eligibility Criteria
Inclusion
- Patients of 60 years or older who are planning to receive cardiac surgery (CABG and/or valve replacement surgery)
Exclusion
- Patients will be excluded if they meet any of the following criteria:
- Refuse to participate;
- Preoperative history of schizophrenia, epilepsia, Parkinson syndrome, or severe dementia;
- Inability to communicate in the preoperative period because of severe visual/auditory dysfunction or language barrier;
- History of brain injury or neurosurgery;
- Preoperative sick sinus syndrome, severe bradycardia (HR \< 50 bpm), second-degree or above atrioventricular block without pacemaker;
- Severe hepatic dysfunction (Child-Pugh class C);
- Severe renal dysfunction (requirement of renal replacement therapy);
- Other conditions that are considered unsuitable for participation.
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
285 Patients enrolled
Trial Details
Trial ID
NCT02267538
Start Date
November 1 2014
End Date
November 1 2015
Last Update
March 5 2018
Active Locations (1)
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1
Peking University First Hospital
Beijing, Beijing Municipality, China, 100034