Status:
WITHDRAWN
Transcranial Stimulation During Sleep to Improve Cognition in Epilepsy
Lead Sponsor:
NYU Langone Health
Conditions:
Epilepsy
Eligibility:
All Genders
18-70 years
Phase:
NA
Brief Summary
Aim 1: Determine whether sleep enhances learning across a range of cognitive domains in healthy subjects. Aim 2: Determine whether low-frequency transcranial stimulation (TCS) delivered during slow w...
Detailed Description
Epilepsy and cognitive dysfunction Recent investigations suggest that more than 60% of patients with epilepsy suffer cognitive impairment, such as memory, attentional and executive dysfunction (Elger ...
Eligibility Criteria
Inclusion
- Age between 18-70 years
- Must score 22 or more on the MoCA.
- Must be able to provide informed consent.
- Must be fluent in English.
- Diagnosis of focal epilepsy
Exclusion
- Patient has a progressive or unstable neurological or systemic disease
- Patient has a history of severe traumatic brain injury or prior brain surgery with skull defect
- Contraindictations to TCS, including metal in the head or implanted brain medical devices
- Pregnancy
- Any implanted electrical medical device, including pacers and implanted cardiac defibrillators
- History of schizophrenia, schizoaffective disorder, other psychosis, rapid-cycling bipolar illness, alcohol/drug abuse within the past year
- History of dementia
- History of known sleep disorder
- Additional Exclusion Criteria
- Ictal Focus over the F3 or F4 field
- Clinical or electrographic evidence of frequent nocturnal seizures, as determined with recent (\<2 year) ambulatory EEG.
- Generalized epilepsy
- Epilepsy subjects will be identified and consented from the NYU Comprehensive Epilepsy Center. In addition to the inclusion and exclusion criteria above, epilepsy subjects must meet the following criteria:
Key Trial Info
Start Date :
May 28 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 27 2014
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02268591
Start Date
May 28 2013
End Date
May 27 2014
Last Update
March 15 2018
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