Status:
COMPLETED
Morbidity in Patients With Hypertension and Obstructive Sleep Apnea
Lead Sponsor:
University of Sao Paulo General Hospital
Collaborating Sponsors:
Financiadora de Estudos e Projetos
Conselho Nacional de Desenvolvimento Científico e Tecnológico
Conditions:
Hypertension
Sleep Apnea, Obstructive
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
MORPHEOS is a multicenter, randomized, unblinded study, for patients diagnosed with uncontrolled hypertension and at least one antihypertensive medication. Those patients with significant sleep apnea ...
Eligibility Criteria
Inclusion
- Systolic blood pressure ≥140 mm Hg or diastolic blood pressure ≥ 90 mm Hg
- Current treatment with at least 1 antihypertensive drug
Exclusion
- Age \<18 and \>65 years
- BMI ≥ 40 kg/m2
- Heart failure, EF \< 45%, acute myocardial infarction, stroke, significant valvular dysfunction
- Chronic renal failure (serum creatinine \> 2 mg/dL)
- Use of cocaine, amphetamines, alcohol, illicit drugs
- Use of sympathomimetics (decongestants, appetite suppressants)
- Use of oral contraceptives and chronic use of NSAIDs
- Pregnancy
- Secondary causes of hypertension (other than sleep apnea)
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2020
Estimated Enrollment :
123 Patients enrolled
Trial Details
Trial ID
NCT02270658
Start Date
January 1 2015
End Date
December 1 2020
Last Update
September 28 2023
Active Locations (5)
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1
Pronto Socorro Cardiológico de Pernambuco (PROCAPE)
Recife, Pernambuco, Brazil, 50100600
2
Hospital das Clínicas de Porto Alegre
Porto Alegre, Rio Grande do Sul, Brazil, 90035903
3
Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto
Ribeirão Preto, São Paulo, Brazil, 14048900
4
Fundação Zerbini - Instituto do Coração (InCor)
São Paulo, São Paulo, Brazil, 054039000