Status:
COMPLETED
Effect of Nicardipine on Renal Function in Deliberate Hypotension
Lead Sponsor:
Yonsei University
Conditions:
Spinal Stenosis
Eligibility:
All Genders
20+ years
Phase:
PHASE4
Brief Summary
The aim of this study was to demonstrate the effect of nicardipine on renal function with creatinine clearance, serum cystatin C, urine output and fractional excretion of sodium during deliberate hypo...
Detailed Description
To induce deliberate hypotension, pharmacological agents such as inhalation anesthetics, calcium channel blockers, beta-adrenergic blockers have been used alone or in combination. Nicardipine, classed...
Eligibility Criteria
Inclusion
- Patients undergoing anterior or posterior spine interbody fusion
Exclusion
- Patients with American Society of Anesthesiologists physical status III or IV
- Liver dysfunction with aspartate transaminase/alanine transaminase greater than 60/60 IU/L
- Cerebrovascular disease
- Anemia of less than hematocrit 24%
- Diabetes mellitus
- Severe malnutrition
- those diuretics or antihypertensive drugs
Key Trial Info
Start Date :
May 1 2012
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2013
Estimated Enrollment :
64 Patients enrolled
Trial Details
Trial ID
NCT02271191
Start Date
May 1 2012
End Date
January 1 2013
Last Update
October 23 2014
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