Status:
RECRUITING
Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults
Lead Sponsor:
Children's Hospital Medical Center, Cincinnati
Conditions:
Respiratory Disorders
Eligibility:
All Genders
6+ years
Phase:
PHASE1
PHASE2
Brief Summary
The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults a...
Detailed Description
Hyperpolarized 129Xe will be produced, by trained staff, using a polarizer housed at Cincinnati Children's Hospital Medical Center. Individual imaging sessions will be done on a single day and will in...
Eligibility Criteria
Inclusion
- Ages 6 and up
- Participant must be able to hold breath for up to 16 seconds
Exclusion
- History of heart defect
- Pregnancy or positive pregnancy test
- History of uncontrolled asthma defined for this study as requiring use of rescue inhaler ≥ 2 times in past month
- Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
- Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
- Participant is claustrophobic and unable to tolerate the imaging.
- Standard MRI exclusions (metal, implants)
Key Trial Info
Start Date :
December 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2029
Estimated Enrollment :
300 Patients enrolled
Trial Details
Trial ID
NCT02272049
Start Date
December 1 2014
End Date
August 31 2029
Last Update
September 10 2025
Active Locations (1)
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1
Cincinnati Children's Hospital Medical Center
Cincinnati, Ohio, United States, 45229