Status:
COMPLETED
Cerebral Blood Flow During Hemodialysis
Lead Sponsor:
University Medical Center Groningen
Collaborating Sponsors:
Martini Hospital Groningen
Conditions:
Haemodialysis-induced Symptom
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
The purpose of this study is to evaluate the effect of the hemodialysis procedure on cerebral blood flow (CBF) in elderly maintenance hemodialysis (HD) patients. The investigators hypothesize that HD ...
Detailed Description
The investigators aim to include 14 participants. Each participant will undergo a single HD study session in the PET center of the UMCG. During this study session, each participant will undergo three ...
Eligibility Criteria
Inclusion
- Adult, age ≥ 65 years, HD patients who have been treated with maintenance HD, of which at least 6 patients for a longer period of time (\>1 year).
- Patients must have an arteriovenous fistula without recirculation
- The hemoglobin value must be in the target range (6.2 - 8mmol/l) since at least 1 month
Exclusion
- The absence of informed consent
- Diagnosis of dementia, hydrocephalus, history of raised intracranial pressure, significant (\>70%) carotid artery stenosis, end-stage liver disease.
- Actively treated cancer
- Actual hospital admission at timing of HD study session
- MRI incompatible implants in the body or any other contraindication for MRI
- Claustrophobia
- The refusal to be informed of significant carotid artery stenosis or structural brain abnormalities that could be detected during the study.
Key Trial Info
Start Date :
April 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 1 2015
Estimated Enrollment :
15 Patients enrolled
Trial Details
Trial ID
NCT02272985
Start Date
April 1 2015
End Date
November 1 2015
Last Update
April 7 2020
Active Locations (1)
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1
University Medical Center Groningen
Groningen, Netherlands, 9713 GZ