Status:
COMPLETED
1% Metformin in Moderate and Severe Periodontitis
Lead Sponsor:
Government Dental College and Research Institute, Bangalore
Conditions:
Periodontitis
Eligibility:
All Genders
30-50 years
Phase:
PHASE2
PHASE3
Brief Summary
This study evaluates the efficacy of 1% Metformin gel in treatment of moderate and severe periodontitis subject.
Detailed Description
Metformin (MF) has stimulating effect of osteoblastic lineages. In the present study seventy subjects were categorized into two treatment groups: Scaling and root planing (SRP) plus 1% MF and SRP plus...
Eligibility Criteria
Inclusion
- Systemically healthy subjects, Pocket depth ≥ 5 mm, Clinical attachment level ≥ 4 mm and vertical bone loss ≥ 3 mm on intraoral periapical radiographs, with no history of periodontal therapy in the last 6 months.
Exclusion
- subjects allergic to MF, those on systemic MF therapy, subjects with aggressive periodontitis, immunocompromised subjects, use of tobacco in any form, alcoholics, lactating and pregnant females.
Key Trial Info
Start Date :
November 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2014
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT02274090
Start Date
November 1 2013
End Date
August 1 2014
Last Update
October 24 2014
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