Status:
COMPLETED
Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery
Lead Sponsor:
Northwell Health
Conditions:
Post-operative Pain
Eligibility:
All Genders
18-74 years
Phase:
PHASE4
Brief Summary
Continuous femoral nerve blocks (CFNB) provide effective pain control to patients undergoing total knee replacement (TKR). However the resulting motor blockade can lead to decreased quadriceps muscle ...
Detailed Description
This is a prospective, randomized, active controlled study in patients undergoing total knee replacement. The objective of this study is to compare the efficacy of Liposome Bupivacaine, in managing po...
Eligibility Criteria
Inclusion
- ASA Status I-III
- Scheduled to undergo primary unilateral total knee arthroplasty
Exclusion
- Patients who are pregnant or nursing
- Alcohol or narcotic dependence within the last 2 years
- Condition requiring regular use of analgesia that may confound post surgical assessments as determined by principle investigator
- BMI \> 40kg/m2
- Contraindication to acetaminophen, morphine, oxycodone, ketorolac, epinephrine, or pathological conditions potentially aggravated by epinephrine
- Allergies to amide-type local anesthetics
- Any disease condition or lab result that could complicate a patients postoperative recovery
- History of hypotension
- Abnormal liver, renal or cardiac function
- Other physical, mental or medical conditions that, in the opinion of the investigator, make study participation inadvisable.
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2017
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT02274870
Start Date
November 1 2014
End Date
January 1 2017
Last Update
June 14 2018
Active Locations (1)
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1
Franklin
Valley Stream, New York, United States, 11580