Status:
RECRUITING
Immune Cell Dysfunction in Severe Alcoholic Hepatitis
Lead Sponsor:
Mid and South Essex NHS Foundation Trust
Conditions:
Hepatitis
Eligibility:
All Genders
18-65 years
Brief Summary
Through bio-sampling this study investigates the relationship between the frequency and function of the cells of a patients immune system and how these change and impact on the outcome of alcoholic he...
Detailed Description
Through bio-sampling this study investigates the relationship between the frequency and function of the cells of a patients immune system and how these change and impact on the outcome of alcoholic he...
Eligibility Criteria
Inclusion
- Age 18-65 years
- Patients presented with severe alcoholic hepatitis with a Maddrey score (discriminant function) of \>32 (The Maddrey score uses various blood results on a patient to define the severity of alcoholic hepatitis e.g.bilirubin etc).
- Ongoing abuse of alcohol (drinking in excess of 28 units/wk)
Exclusion
- Co-infection with HIV/Hepatitis B / Hepatitis C virus infection.
- Patients with autoimmune liver disease.
- Patients with metabolic liver disease.
- Patients with significant psychiatric and/or neurological co-morbidity.
- Hepatocellular carcinoma or other neoplastic disease
- Pregnancy or breast feeding of infants.
Key Trial Info
Start Date :
November 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT02275195
Start Date
November 1 2013
End Date
December 1 2024
Last Update
January 12 2024
Active Locations (1)
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1
Basildon Hospital
Basildon, Essex, United Kingdom, SS16 5NL