Status:
COMPLETED
Kidney Response to Sepsis Affects Angiogenic Balance and Likelihood of CCI and PICS
Lead Sponsor:
University of Florida
Collaborating Sponsors:
National Institutes of Health (NIH)
National Institute of General Medical Sciences (NIGMS)
Conditions:
Sepsis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This study investigates the mechanism by which kidney dysfunction perpetuates inflammation, immunosuppression, and catabolism (PICS) in chronic critical illness. The investigators will test the hypoth...
Detailed Description
The main goal of this project is to measure kidney filtration function at day 14 or the day of discharge from hospital (whichever occurs first), in order to determine the presence and magnitude of per...
Eligibility Criteria
Inclusion
- Presence in the surgery or trauma ICU
- Age of ≥18 years
- Entrance into our sepsis protocol
- Ability to obtain informed consent.
Exclusion
- Expected lifespan of the patient is less than 3 months due to severe pre-existing comorbidities (ex. recurrent, advanced or metastatic cancer)
- Severe traumatic brain injury (evidence of neurologic injury on CT scan and a GCS \<8)
- Refractory shock (i.e., patients who die within 12 hours)
- Uncontrollable source of sepsis (e.g., irreversible disease state such as unresectable dead bowel)
- Patient or patient's family are not committed to aggressive management of the patient's condition and/or the patient has a DNR/DNI on file.
- Severe CHF (NY Heart Association Class IV)
- Child-Pugh C liver disease or pre-liver transplant.
- Known HIV infection with CD4 count \<200 cells/mm3
- Organ transplant recipient on immunosuppressive agents
- Known pregnancy and mother's that are breastfeeding
- Prisoners
- Institutionalized patients
- Inability to obtain informed consent.
- Chemotherapy or radiotherapy within 30 days prior to sepsis.
- End stage renal disease on admission.
Key Trial Info
Start Date :
February 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 20 2023
Estimated Enrollment :
73 Patients enrolled
Trial Details
Trial ID
NCT02276066
Start Date
February 1 2015
End Date
May 20 2023
Last Update
July 9 2024
Active Locations (1)
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1
UF Health at Shands hospital
Gainesville, Florida, United States, 32610