Status:
COMPLETED
Oxytocin Effects on Food Motivation Pathways
Lead Sponsor:
Massachusetts General Hospital
Conditions:
Overweight and Obesity
Eligibility:
MALE
18-45 years
Phase:
EARLY_PHASE1
Brief Summary
Oxytocin is a peptide hormone produced in the brain that regulates food intake. However, the mechanisms for this effect in humans is not yet clear. In this study, the investigators will therefore exa...
Eligibility Criteria
Inclusion
- Age 18-45 years old
- BMI 25-40
- Regular breakfast eater (at least 4 times per week)
- Stable weight within the past three months
Exclusion
- Psychiatric disease, use of psychotropic medications
- History of eating disorder
- History of excessive exercise within the last three months (having run more that 25 miles in any one week or having exercised more than ten hours in any one week)
- History of diabetes mellitus
- Active substance abuse
- Hematocrit lower than the normal range
- Gastrointestinal tract surgery (including gastrectomy, gastric bypass surgery, and small or large bowel resection)
- History of cardiovascular disease (such as hypertrophic cardiomyopathy, valvular heart disease, coronary heart disease, or coronary artery spasms)
- Untreated thyroid disease
- Tobacco use
- Cardiac pacemaker, surgical aneurysm clips, neurostimulator, implanted pumps, metal fragments in body/eyes, nitroglycerin patch, severe claustrophobia
Key Trial Info
Start Date :
October 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2015
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT02276677
Start Date
October 1 2014
End Date
May 1 2015
Last Update
April 8 2019
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114