Status:
COMPLETED
Comparison of Different Weight Loss Diets With Different Protein Content
Lead Sponsor:
National University of Singapore
Conditions:
Weight Loss
Insulin Resistance
Eligibility:
All Genders
21-45 years
Phase:
NA
Brief Summary
High-protein diets better preserve lean mass than conventional low-fat diets. However, they are costly and have potential health risks. Preserving lean mass is important for sustaining high resting en...
Detailed Description
The prevalence of obesity globally and in Singapore continues to rise despite increased public awareness and efforts to control weight. Its association with chronic metabolic diseases, including diabe...
Eligibility Criteria
Inclusion
- Be willing and able to comply with study procedures and given written informed consent
- Chinese, aged 21-45 years old
- Body mass index (BMI) between 25 -35 kg/m2 and % body fat of more than 25 %.
- Sedentary adults, with \<1 episode of exercise per week
- Not have a history of food allergies or food intolerances
- Have maintained a stable body weight for at least 3 months prior to the study.
- Be a non-smoker
- Drinks less than 3 caffeinated beverages per day (coffee/tea/energy drinks)
- Drinks less than 3 units of alcohol per day
Exclusion
- Subjects with diabetes, renal impairment, high blood pressure, gastrointestinal problems, asthma, eczema, anaemia or on medications that will affect glucose metabolism (e.g. corticosteroids) or lipid metabolism/insulin resistance (e.g. niacin, fibrates, metformin) and other significant medical conditions, which in the investigator's opinion would confound interpretation of results.
- Recent changes (gain or loss) in weight of \>5% over the past 3 months
- Significant changes in diet over the past 3 months
- Any use of weight-reduction drugs in the past 6 months
- Use of any prescription medication that cannot be safely discontinued within 14 days prior to study entry
- Have special dietary needs/restrictions e.g. vegetarian diet or unable to consume fish, seafood and beef
- History of eating disorders or irregular eating habits
- High level of physical activity (exercise \> 5hr per week)
- Women who are pregnant and lactating and women of reproductive age group who plan to conceive within 6 months. A pregnancy test will be performed for women in the reproductive age group.
- Have contraindications to Magnetic Resonance Imaging (MRI) that includes metallic implants, pacemakers or stimulators, or any other methodology applied in the study.
- Have been involved in any clinical or food study within the preceding month.
- Presently consuming amino acid or protein-related supplements.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2018
Estimated Enrollment :
109 Patients enrolled
Trial Details
Trial ID
NCT02277275
Start Date
August 1 2014
End Date
July 1 2018
Last Update
March 13 2019
Active Locations (1)
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1
Clinical Nutrition Research Center
Singapore, Singapore, 117599