Status:
COMPLETED
Comparison of Epidural Oxycodone and Epidural Morphine
Lead Sponsor:
KK Women's and Children's Hospital
Conditions:
Pruritus
Eligibility:
FEMALE
21-50 years
Phase:
PHASE3
Brief Summary
The primary objectives of this study are to compare the efficacy of pain relief between epidural oxycodone and epidural morphine for postoperative analgesia after elective caesarean section and to com...
Detailed Description
Undesirable side effects such as pruritus and nausea are common with epidural morphine and are thought to be due to mu-opioid receptor stimulation at the supra-spinal level. Recent studies of epidural...
Eligibility Criteria
Inclusion
- American Society of Anesthesiologists (ASA) physical status 1-2,
- aged between 21 to 50 years undergoing a term elective caesarean section and
- had consented for combined spinal-epidural (CSE) anaesthesia
Exclusion
- concurrent opioid therapy,
- contraindications to CSE anaesthesia or any of the study medications,
- a history of pre-existing nausea and vomiting,
- failure to identify intrathecal space at time of anaesthesia,
- inadvertent dural puncture with the epidural needle and
- conversion of regional anaesthesia to general anaesthesia
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT02277678
Start Date
August 1 2013
End Date
December 1 2014
Last Update
September 4 2015
Active Locations (1)
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1
KK Women's and Children's Hospital
Singapore, Singapore, Singapore, 229899