Status:
COMPLETED
A Comparison of the Neurocognitive and Metabolic Effects of Fructose, Glucose, High Fructose Corn Syrup and Sucrose at Normal Population Consumed Levels in Adults Ages 20-60 Years Old
Lead Sponsor:
Rippe Lifestyle Institute
Conditions:
Conditions: None. Focus: Understanding the Obesogenic Potential of Fructose Containing Sugars
Eligibility:
All Genders
20-60 years
Phase:
NA
Brief Summary
The purpose of this study is to investigate the acute and chronic effects of consumption fructose containing sugars and glucose in a real word setting when consumed in a manner and amount typical in t...
Detailed Description
Detailed description (Why and How?) Fructose is known to be metabolized differently than the other common monosaccharides. In addition to the well know lipogenic effects, more recent evidence has show...
Eligibility Criteria
Inclusion
- Male or female between the ages of 20-60 years of age.
- Body Mass Index (BMI) 21.0 - 35.0
Exclusion
- More than a 3 percent change in weight within the 3 months prior to enrollment in the study.
- History of thyroid disease, but not taking medication or medication dosage changed one or more times over last 6 months. History of thyroid disease and on a stable dose of prescription medication for 6 months or longer is acceptable.
- Currently taking a prescription medication for weight loss. If subject is willing to discontinue prescription medication(s) immediately and willing to refrain from taking medication(s) for duration of study, he/she may be enrolled after a four-week washout period.
- Currently taking any over-the-counter weight loss supplement(s). If subject is willing to discontinue supplement(s) immediately and willing to refrain from taking supplement(s) for duration of study, he/she may be enrolled after a two-week washout period.
- Currently enrolled in commercial weight loss program (e.g. Jenny Craig, Weight Watchers) or self-help group (e.g. TOPS, Overeaters Anonymous). If subject is willing to discontinue program immediately and willing to refrain from program for duration of study, he/she may be included after a two-week washout period.
- Diagnosed with prediabetes or frank diabetes (Type I or Type II).
- History of major surgery within three months of enrollment.
- History of heart problems (e.g. angina, bypass surgery, MI, etc.) within three months prior to enrollment.
- Presence of implanted cardiac defibrillator or pacemaker.
- Uncontrolled hypertension/high blood pressure.
- History of a surgical procedure for weight loss at any time (e.g. gastroplasty, gastric by-pass, gastrectomy or partial gastrectomy).
- Gastrointestinal disorders including chronic malabsorptive conditions, peptic ulcer disease, Crohn's disease, chronic diarrhea or active gallbladder disease.
- History of inflammatory bowel disease
- History of fatty liver
- History or presence of cancer. Persons with successfully resected basal cell carcinoma of the skin may be enrolled if treatment completed more than 6 months prior to enrollment.
- History of clinically diagnosed eating disorders including anorexia nervosa, bulimia nervosa or binge eating disorder.
- Women who are pregnant, lactating or trying to become pregnant.
- Currently taking any prescription medication for less than 3 months.
- Currently consuming \>14 alcoholic drinks (1 drink = 12 fl oz beer, 4 fl oz wine or 1.5 fl oz liquor) per week and/or unwilling to limit intake to less than 3 drinks per week during study participation.
- Known allergy to HFCS, sucrose, fructose or glucose.
- History of alcohol dependency
- Participation in another clinical trial within 30 days prior to enrollment.
- Lactose intolerance
- Currently smoking cigarettes
- Any clinically significant food allergy
Key Trial Info
Start Date :
June 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
Estimated Enrollment :
225 Patients enrolled
Trial Details
Trial ID
NCT02278042
Start Date
June 1 2013
Last Update
April 10 2015
Active Locations (1)
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1
Rippe Lifestyle Institute
Celebration, Florida, United States, 34747