Status:
COMPLETED
Tau Imaging in Professional Fighters
Lead Sponsor:
Avid Radiopharmaceuticals
Collaborating Sponsors:
The Cleveland Clinic
Conditions:
Alzheimer's Disease
Eligibility:
MALE
18+ years
Phase:
PHASE1
Brief Summary
Subjects enrolled in the Professional Fighters Brain Health Study (PFBHS) will receive flortaucipir to explore its use as a biomarker for brain injury related to repetitive head trauma and to examine ...
Eligibility Criteria
Inclusion
- All Subjects
- Currently enrolled in the PFBHS protocol and have participated in a minimum of 10 professional fights
- Can tolerate Positron Emission Tomography (PET) scan procedures
- Have the ability to provide informed consent
- Subjects with cognitive impairment
- Have subjective cognitive complaints or objective decline or impairment as determined by the investigator
Exclusion
- Have behavior dysfunction that is likely to interfere with imaging
- Are claustrophobic or otherwise unable to tolerate the imaging procedure
- Have current clinically significant cardiovascular disease or clinically significant abnormalities on screening electrocardiogram
- A history of additional risk factors for Torsades de Pointes (TdP) or are taking drugs that are known to cause QT-prolongation
- Have a current clinically significant infectious disease, endocrine or metabolic disease, pulmonary, renal or hepatic impairment, or cancer
- Have had a non-study related radiopharmaceutical imaging or treatment procedure within 7 days prior to the study imaging session
- Have current drug or alcohol dependence or alcohol dependence within the past 2 years
Key Trial Info
Start Date :
February 18 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 3 2017
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT02278354
Start Date
February 18 2015
End Date
February 3 2017
Last Update
September 10 2020
Active Locations (1)
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1
Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas, Nevada, United States, 89106