Status:
UNKNOWN
Cholinergic Anti-inflammatory Pathway in Prevention & Treatment of the SIRS in Patients With Jaundice After Operation.
Lead Sponsor:
Wanqing Gu
Conditions:
Systemic Inflammatory Response Syndrome
Jaundice, Obstructive
Eligibility:
All Genders
18-80 years
Phase:
PHASE1
PHASE2
Brief Summary
RATIONALE:Anticholinesterase drugs and cholinergic M receptor antagonist are applied to patients who have obstructive jaundice after operation. PURPOSE:This clinical trial was designed to lower the i...
Detailed Description
OBJECTIVES: Ⅰ.Judge whether it has the effect of inhibiting inflammation, anti oxidative stress and anti apoptosis when the alpha 7 nicotinic acetylcholine receptors are activated . Ⅱ.Judge whether ...
Eligibility Criteria
Inclusion
- Ⅰ.Accompanied by obstructive jaundice and plans to implement the liver resection of hilar bile duct carcinoma.
- Patients with carcinoma of head of pancreas and plans to implement pancreaticoduodenectomy.
- Ⅱ. Drugs which were used in the clinical trials is safe for patients.
- Ⅲ.The patients did not occur the complication which would affect the experimental observation seriously after the operation.
- Ⅳ.The patients agreed to participate in this clinical trial and sign the informed consent.
Exclusion
- Ⅰ.Patients are unwilling to accept the clinical trials or researchers believe that patients can not in compliance with the requirements of clinical research.
- Ⅱ.Patients with tumor metastases widely or can not accept a predetermined operation scheme.
- Ⅲ. The postoperative complications or other therapeutic measures take will affect the experimental observation seriously.
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2017
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT02279147
Start Date
August 1 2014
End Date
September 1 2017
Last Update
October 30 2014
Active Locations (1)
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1
CHN Chinese PLA General Hospital
Beijing, Beijing Municipality, China, 100853