Status:
COMPLETED
Incidence and Risk Factors for Infections in Patient Treated With Corticosteroids, Immunosuppressive Drugs or Biotherapy for Immunologic and Inflammatory Diseases
Lead Sponsor:
University Hospital, Bordeaux
Collaborating Sponsors:
Ministry for Health and Solidarity, France
Conditions:
Immunologic and Inflammatory Diseases
Eligibility:
All Genders
18+ years
Brief Summary
Infections represent the first cause of death and of morbidity in people treated for immunologic and inflammatory diseases with corticosteroids, immunosuppressive drugs or biotherapy. Epidemiological,...
Detailed Description
Monitoring of neutrophils, lymphocytes, immune activation markers, immunoglobulins have not been prospectively studied in such patients. Preliminary retrospective studies have shown that total lymphop...
Eligibility Criteria
Inclusion
- Age \> 18 years
- Immune or inflammatory disease : Lupus, antiphospholipid syndrome, Sjogren syndrome, inflammatory myositis, immunologic thrombopenic purpura, autoimmune hemolytic anemia, Evan's syndrome, systemic vasculitis, Behcet disease.
- Indication of corticosteroid therapy \> 20 mg for at least 3 months and/or immunosuppressive or biologic agent.
- Information consent
Exclusion
- Previous treatment with immunosuppressive or biological agents, or cumulative dose of steroids \> 1g last 6 months
- Splenectomy
- Pregnancy
- Evoluting Cancer
Key Trial Info
Start Date :
February 16 2016
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 19 2021
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT02280902
Start Date
February 16 2016
End Date
November 19 2021
Last Update
February 3 2022
Active Locations (7)
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1
Service de Médecine Interne - CH d'Agen
Agen, France, 47923
2
Service de Médecine Interne et maladies Infectieuses - Hôpital Saint-André
Bordeaux, France, 33075
3
service de médecine interne - CH de Libourne
Libourne, France
4
Service de Médecine Interne - CHU de Limoges
Limoges, France, 87042