Status:
TERMINATED
Itraconazole for Fungal Sensitive Chronic Rhinosinusitis With Nasal Polyps
Lead Sponsor:
The University of Texas Health Science Center, Houston
Conditions:
Chronic Rhinosinusitis
Eligibility:
All Genders
18-75 years
Phase:
PHASE2
PHASE3
Brief Summary
The purpose of this randomized controlled double-blinded trial is to determine if the addition of an oral antifungal to typical post-operative medical therapy can prevent or reduce the incidence of re...
Detailed Description
CRSwNP patients scheduled for medically-indicated sinus surgery will undergo screening ELIspot assay to identify patients with fungal sensitivity based on positive fungal induced interleukin 4 (IL-4) ...
Eligibility Criteria
Inclusion
- Meet criteria for diagnosis of CRS with nasal polyps undergoing medically indicated sinus surgery
Exclusion
- cystic fibrosis
- aspirin exacerbated respiratory disease
- uncontrolled or unstable chronic diseases such as uncontrolled diabetes
- active or history of cancer
- HIV positive
- history of liver or kidney disease
- history of disease with effects on immune system
- pregnant
- allergy to triazole antifungals
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 15 2019
Estimated Enrollment :
58 Patients enrolled
Trial Details
Trial ID
NCT02285283
Start Date
November 1 2014
End Date
May 15 2019
Last Update
October 28 2020
Active Locations (1)
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1
University of Texas Medical School at Houston
Houston, Texas, United States, 77030