Status:
COMPLETED
Comparisons of Two Low-density Lipoprotein Apheresis Systems in Patients With Homozygous Familial Hypercholesterolemia
Lead Sponsor:
Laval University
Conditions:
Homozygous Familial Hypercholesterolemia
Eligibility:
All Genders
18-60 years
Brief Summary
Homozygous familial hypercholesterolemia (HoFH) is characterized by a six- to eight-fold raise in plasma LDL-cholesterol (LDL-C) concentrations and atherosclerotic coronary artery disease usually occu...
Eligibility Criteria
Inclusion
- Aged between 18-65 years
- Subjects with homozygous familial hypercholesterolemia:
- Carrier of a mutation in the LDL receptor gene
Exclusion
- Subjects with a previous history of cardiovascular disease
- Subjects with Type 2 diabetes
- Were pregnant or nursing;
- Subjects with a history of cancer
- Subjects with acute liver disease, hepatic dysfunction, or persistent elevations of serum transaminases
- Subjects with a secondary hyperlipidemia due to any cause
- History of alcohol or drug abuse within the past 2 years
- hormonal treatment
- Subjects who are in a situation or have any condition that, in the opinion of the investigator, may interfere with optimal participation in the study
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2014
Estimated Enrollment :
9 Patients enrolled
Trial Details
Trial ID
NCT02286596
Start Date
April 1 2013
End Date
December 1 2014
Last Update
March 8 2016
Active Locations (1)
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1
Institute of Nutrition and Functional Foods (INAF)
Québec, Quebec, Canada, G1V 0A6