Status:
COMPLETED
Creatine, Exercise and Inflammatory Markers in Knee Osteoarthritis
Lead Sponsor:
University of Manitoba
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
45-65 years
Phase:
NA
Brief Summary
The goal of this research project is to determine the effectiveness of creatine supplementation and supported low-load walking exercise for managing systemic inflammatory biomarkers and joint symptoms...
Detailed Description
Participants will provide informed consent, complete participant information and knee demographic forms, and undergo radiographic evaluation to confirm eligibility. Baseline evaluation of (1) systemic...
Eligibility Criteria
Inclusion
- (1) Ages 45-65; (2) Body mass index (BMI) over 25 kg/m2; (3) Knee pain when performing normal activities of daily living (walking, squatting, or kneeling); (4) Kellgren \& Lawrence grades II \& III radiographic evidence of mild to moderate knee osteoarthritis in one or both knees.
Exclusion
- (1) Radiographic evidence of severe knee osteoarthritis; (2) History of traumatic hip, knee, or ankle injury or surgery; (3) Use of crutches or a walking aid during ambulation; (3) History of medical conditions that prevent physical activity; (4) Unable to provide consent due to language barrier or mental status; (5) History of diabetes, cardiovascular disease, or screen positive for ankylosing spondylitis, psoriatic arthritis, chronic reactive arthritis, or renal problems requiring peritoneal dialysis or hemodialysis; (6) Unwillingness or inability to return for follow-up appointments.
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2016
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT02290275
Start Date
January 1 2015
End Date
April 1 2016
Last Update
May 16 2016
Active Locations (1)
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1
Alison Longo
Winnipeg, Manitoba, Canada, R3M 3E4