Status:
COMPLETED
Strength Testing After Nitrate Delivery (STAND) in ICU Patients
Lead Sponsor:
Wake Forest University Health Sciences
Conditions:
Respiratory Failure
Eligibility:
All Genders
56+ years
Phase:
NA
Brief Summary
It is well documented that intensive care unit (ICU) patients have lower levels of skeletal muscle strength compared to non-ICU patients upon hospital discharge, and this weakness affects the patient'...
Detailed Description
The proposed study is an investigator initiated, double blind, placebo controlled experimental study designed to evaluate the effect of chronic NO3- supplementation via beetroot juice ingestion on the...
Eligibility Criteria
Inclusion
- Age \> 55 years
- Mechanically ventilated via an endotracheal tube or mask who have begun spontaneous breathing trials or extubated within the previous 24 hours
- Lung Injury as defined by a PaO2 / FiO2 \< 300
Exclusion
- Inability to walk without assistance prior to acute ICU illness (use of a cane or walkers not exclusions)
- Cognitive impairment prior to acute ICU illness (non-verbal)
- Acute stroke
- Body mass index (BMI) \>50
- Neuromuscular disease that could impair weaning (myasthenia gravis, ALS, Guillain-Barre)
- Hip fracture, unstable cervical spine or pathological fracture
- Mechanically Ventilated \> 80 hours
- Current hospitalization or transferring hospital stay \> 7 days
- DNR/DNI on admission
- Cancer treatment within the last 6 months
- Moribund
- Participation in another research study
- On nitroglycerine or nitrate preparations used with angina or phosphodiesterase type 5 inhibitors
- Body mass less than 60 kg
Key Trial Info
Start Date :
June 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2017
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT02293616
Start Date
June 1 2015
End Date
April 1 2017
Last Update
July 18 2018
Active Locations (1)
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1
Wake Forest University Health Sciences
Winston-Salem, North Carolina, United States, 27157