Status:
COMPLETED
Integrated Approaches to Food Allergen and Allergy Risk Management
Lead Sponsor:
University of Zurich
Collaborating Sponsors:
Cork University Hospital
Charite University, Berlin, Germany
Conditions:
Food Allergy
Eligibility:
All Genders
5+ years
Phase:
NA
Brief Summary
Patients with history of a food allergy to hazelnut, walnut or celeriac will undergo food provocation with a dose of the allergenic food to which 5% of the respective food allergic population (ED05) h...
Detailed Description
single shot study, matrix comparison and walnut/PPI study 1. detailed case history, blood sampling and prick testing with different foods will performed. 2. food provocation with a chocolate dessert ...
Eligibility Criteria
Inclusion
- Signed informed consent
- For single shot study: history of a hazelnut, walnut, celeriac allergy due to an unequivocal accidental exposure with typical acute allergic reaction within the preceding 2 years and positive allergen-specific skin prick test/specific Immunoglobulin E or recent positive oral food challenge with hazel, walnut or celeriac within previous 2 years in children \<16 years, but no time limit specified for adults
- For matrix comparison study: history of peanut or hazelnut allergy
- For walnut/PPI study: history of walnut allergy. The minimum age for this study is 18 years
Exclusion
- Severe disease (heart, liver, kidney), acute febrile infection
- Intake of Ketotifen (past 2 weeks), corticosteroids (past 2 weeks), histamine-1-receptor blocker (past 3 days apart first generation past 7 days)
- Anaphylactic reaction (past 4 weeks)
- Uncontrolled bronchial asthma, forced expiratory volume \< 70% predicted
- Pregnancy
- Acute infection or allergy
- Uncontrolled atopic dermatitis
- Chronic urticaria
- Mastocytosis
- Uncontrolled hypertension
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 1 2017
Estimated Enrollment :
72 Patients enrolled
Trial Details
Trial ID
NCT02295397
Start Date
November 1 2014
End Date
February 1 2017
Last Update
May 11 2017
Active Locations (1)
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1
Allergy Unit, Department of Dermatology, University Hospital
Zurich, Switzerland, 8091