Status:
TERMINATED
Vaccination Response in Individual Monozygotic Twins
Lead Sponsor:
Michigan State University
Conditions:
Individuality
Asthma
Eligibility:
All Genders
18-80 years
Brief Summary
Respiratory viruses are known to be risk factors for asthma (e.g respiratory syncytial viruses, RSVs, and Human Rhinoviruses, HRVs, may induce bronchiolitis, and wheezing illnesses respectively). The ...
Detailed Description
Asthma pathogenesis and exacerbations have been associated to multiple risk factors, particularly respiratory viruses. In children respiratory syncytial viruses (RSVs) may induce bronchiolitis, and Hu...
Eligibility Criteria
Inclusion
- Volunteers are eligible to participate in this study if both they and their twin sibling have agreed to participate. If after their enrollment in the study, one of the twin siblings decides to withdraw, then:
- If one sibling withdraws during Year 1, the other sibling will be allowed to continue their participation in the study and to complete the current study Year. However they will not be included in the randomly selected applicants that will continue participation in Year 2 of the study.
- If one sibling withdraws duringYear2, the other sibling will be able to conclude Year2 study activities. -
Exclusion
- Volunteer is under18.
- Presence of any medical conditions that the study investigators believe will affect participation in the study or its results.
- Presence of a mental incapacity and/or cognitive impairment that would prevent a subject from adequately understanding, or cooperating with, the study protocol.
- Volunteers with any severe allergies (life-threatening) or that have ever had a life-threatening allergic reaction after a dose of flu vaccine, or have a known severe allergy to any part of this vaccine, will be advised not to participate.
- If a potential subject has ever had Guillain-Barré Syndrome (a severe paralyzing illness, also called GBS), they will be advised not to get the influenza vaccine and be excluded from this study.
- For female participants If they are already enrolled and become pregnant during this study, the investigators will temporarily withdraw them from the study from the day they become pregnant. If they would like to stay in the study, the investigators may continue their participation after their delivery.
- If participants are not feeling well on the scheduled day of vaccination the investigators will suggest that they postpone the vaccination until they feel better. If they agree, the vaccination will be re-scheduled for a later date.
Key Trial Info
Start Date :
October 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 1 2015
Estimated Enrollment :
1 Patients enrolled
Trial Details
Trial ID
NCT02296359
Start Date
October 1 2014
End Date
August 1 2015
Last Update
August 14 2015
Active Locations (1)
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1
Clinical and Translational Science Institute
East Lansing, Michigan, United States, 48824