Status:
UNKNOWN
Dexmedetomidine Effect on Mitochondrial Function
Lead Sponsor:
The Hospital for Sick Children
Conditions:
Complication of Anesthesia
Ischaemia-reperfusion Injury
Eligibility:
All Genders
3-36 years
Phase:
PHASE4
Brief Summary
The investigators hypothesize that in addition to a known sympatholytic effect, intraoperative dexmedetomidine reduces adverse changes in mitochondrial function and structure attenuating ischaemia-rep...
Detailed Description
PICO: For children with non cyanotic congenital heart defects having corrective heart surgery (P) does intraoperative dexmedetomidine (I) reduce real-time changes in mitochondrial function and content...
Eligibility Criteria
Inclusion
- aged between 3 - 36 months
- having primary corrective heart surgery
Exclusion
- recent surgery (\< 3 months)
- previous chemotherapy
- previous transfusion of blood products
- neurodevelopmental disorders (including Trisomy 21)
- supplemental oxygen requirement (\< 3 months)
- asthma requiring regular therapy
- obstructive sleep apnea
- the presence of concurrent infection or inflammation
- a known allergy to dexmedetomidine hydrochloride
Key Trial Info
Start Date :
November 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT02299063
Start Date
November 1 2014
End Date
December 1 2019
Last Update
May 9 2018
Active Locations (1)
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1
Hospital for Sick Children
Toronto, Ontario, Canada, M5G1X8