Status:
COMPLETED
An InnovaTive Approach to Ventilator-Induced Diaphragmatic Dysfunction
Lead Sponsor:
University Hospital, Antwerp
Conditions:
Ventilator-induced Diaphragm Dysfunction
VIDD
Eligibility:
All Genders
18+ years
Brief Summary
'Ventilator-Induced Diaphragmatic Dysfunction (VIDD) was originally described by Vassilakopoulos and Petrof in 1998, where it is used to cover the effects of mechanical ventilation and respiratory mus...
Eligibility Criteria
Inclusion
- The patient must suffer from respiratory insufficiency requiring mechanical ventilation
Exclusion
- The patient has been hospitalized and mechanically ventilated (invasive or non- invasive) in the period up to 1 year before start of the study.
- The patient is known or suspected to have an anatomical malformation of the diaphragm.
- The patient suffers from a disease that may impair diaphragmatic function:
- Central neural disease at the level of the brain (Multiple sclerosis, stroke, Arnold-Chiari malformation) and spinal cord (quadriplegia, amyotrophic lateral sclerosis, poliomyelitis, spinal muscular atrophy, syringomyelia).
- Neural disease of the phrenic nerve (Guillain-Barré syndrome, tumor compression, neuralgic neuropathy, chronic inflammatory demyelinating polyneuropathy, Charcot-Marie-Tooth disease).
- Disorders of the neuromuscular junction (Myasthenia gravis, Lambert- Eaton syndrome, botulism, organophosphate poisoning).
- Muscular diseases (muscular dystrophies, myositis (infectious, inflammatory, metabolic).
- The patient is known or suspected to have a psychiatric illness inhibiting his/her cooperation with the study protocol or possibly obscuring the obtained results.
- The patient has been mechanically ventilated for over 24 hours before the first ultrasonographic measurement can be performed.
Key Trial Info
Start Date :
April 1 2013
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2015
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT02299986
Start Date
April 1 2013
End Date
June 1 2015
Last Update
June 24 2015
Active Locations (1)
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1
Antwerp University Hospital
Edegem, Antwerp, Belgium, 2650