Status:
COMPLETED
Pharmacokinetic Analysis of Midazolam and Fentanyl in Pediatric Patients With Long-term Analgosedation
Lead Sponsor:
Universitätsklinikum Hamburg-Eppendorf
Conditions:
Deep Sedation
Intensive Care Pediatric
Eligibility:
All Genders
28-17 years
Brief Summary
Pharmacokinetic monitoring of midazolam, it's active metabolite and fentanyl in pediatric patients with long-term analgosedation will be performed. Especially, the chronologic sequence of the quantifi...
Detailed Description
At pre-defined timepoints (see below) serum Levels of the above mentioned drugs and metabolites will be determined and pharmakokinetic (PK) modeling will be performed. PK data will be correlated to se...
Eligibility Criteria
Inclusion
- pediatric patients between 28 days and 17 years of age
- mechanical ventilation more than 3 days
- analgosedation with midazolam and fentanyl
Exclusion
- missing informed consent
Key Trial Info
Start Date :
October 1 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
October 1 2018
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT02302391
Start Date
October 1 2014
End Date
October 1 2018
Last Update
April 30 2021
Active Locations (1)
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1
University Medical Center Hamburg-Eppendorf
Hamburg, Germany, 20246