Status:
COMPLETED
Ussing Experiments to Evaluate the Role of Medication-induced Microscopic Colitis
Lead Sponsor:
Maastricht University Medical Center
Conditions:
Microscopic Colitis
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
Medication use, especially NSAIDs and PPIs, prior to diagnosis is considered a risk factor for MC development. However, the exact pathophysiological mechanism is unclear. It is hypothesized that NSAID...
Eligibility Criteria
Inclusion
- The indication for colonoscopy is a relapse of MC (active) / MC in remission (remission) / no MC (control)
- Patient is not treated with NSAIDs / PPI / SSRI in week before inclusion
Exclusion
- Age below 18 years at the time of diagnosis
- Use of anticoagulants or immunosuppressive drugs
- Severe co-morbidities hindering an endoscopic procedure
- A previous history of any type of chronic colitis, IBS, IBD, colon carcinoma or (partial) colectomy
- A recent (last year) diagnosis of infectious diarrhea or radiation proctitis.
- Use of medication known to influence intestinal permeability
- Excessive alcohol usage (\>20 standard units per week)
- Not capable of signing an informed consent
Key Trial Info
Start Date :
November 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2016
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT02303132
Start Date
November 1 2015
End Date
July 1 2016
Last Update
July 19 2016
Active Locations (1)
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1
Maastricht University Medical Center
Maastricht, Netherlands, 6229 HX