Status:
COMPLETED
Effects of Exercise on Cognitive Function in Glioma Patients
Lead Sponsor:
Tilburg University
Conditions:
Low Grade Glioma of Brain
Anaplastic Glioma of Brain
Eligibility:
All Genders
Phase:
NA
Brief Summary
The objective of this pilot randomized controlled trial (RCT) is to assess the feasibility and to determine the effect size of an exercise program in improving objective cognitive functioning.
Detailed Description
Clinical stable patients with 1) low grade glioma (LGG) or 2) anaplastic glioma under age 70 will undergo a home-based exercise program (intervention) or will be assigned to the active controle group....
Eligibility Criteria
Inclusion
- Grade II and III gliomas
- age \< 50 years
- Karnofsky score \> or equal 80
- clinically stable for a minimum of 6 months prior to study entry
- no recent anti-tumor treatment
- interested in undergoing a physical exercise program
- mild to moderate neuropsychological impairment based on normative comparison of objective test performance
- relative VO2peak that leaves room for further improvement of cardiorespiratory fitness.
Exclusion
- patients with serious orthopedic conditions or motor deficits
- patients with serious cardiovascular, cardiopulmonary and neurological conditions (or risks)
- patients judged to have psychiatric (including alcohol and drug abuse)
- patients with severe cognitive problems
- patients who report to engage in vigorous exercise (≥7 METs) for more than 20 minutes on at least 3 days per week on a regular basis will be excluded
- For assessment purposes, study participants will need to have basic fluency in the Dutch language.
Key Trial Info
Start Date :
August 1 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 1 2015
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT02303938
Start Date
August 1 2013
End Date
July 1 2015
Last Update
August 4 2015
Active Locations (1)
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1
Tilburg University
Tilburg, Nood-Brabant, Netherlands, 5037 AB