Status:
UNKNOWN
Effect of Subanesthetic Dose of Ketamine Combined With Propofol on Cognitive Function in Depressive Patients Undergoing Electroconvulsive Therapy
Lead Sponsor:
First Affiliated Hospital of Chongqing Medical University
Conditions:
Depressive Symptoms
Impaired Cognition
Eligibility:
All Genders
18-65 years
Phase:
PHASE4
Brief Summary
Electroconvulsive therapy (ECT) is an effective treatment for depression compared with the current antidepressant agents，but the most important side effect is cognitive dysfunction. The purpose of thi...
Detailed Description
Depression is one of the most debilitating and widespread illnesses affecting up to 20% of individuals in their lifetime. However, the current antidepressant agents take weeks to work, and fail to hel...
Eligibility Criteria
Inclusion
- diagnosed with moderate or severe depression according to Diagnostic and Statistical Manual of Mental Disorders
- aged from 18 to 65 years old
Exclusion
- cerebrovascular malformation, arterial aneurysm, hypertension, or glaucoma;
- classification of American Society of Anesthesiologists physical status score IV or V;
- complications such as respiratory disease, cardiovascular disease, intracranial hypertension, cerebral vascular disorder;
- presence of a foreign body such as pacemaker, intracranial electrode, and clips;
- history of seizures;
- history of drug abuse;
- concomitant presence of a mental disorder;
- pregnancy;
- history of serious adverse effects related to anesthetics;
- refusal to consent for the study, or refusal to undergo one single ECT during the first week of therapy.
- hyperthyreosis
Key Trial Info
Start Date :
January 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
February 1 2017
Estimated Enrollment :
132 Patients enrolled
Trial Details
Trial ID
NCT02305394
Start Date
January 1 2015
End Date
February 1 2017
Last Update
December 2 2014
Active Locations (1)
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1
China,Chongqing The First Affiliated Hospital of Chongqing Medical University
Chongqing, Chongqing Municipality, China, 400016