Status:
UNKNOWN
Does Duloxetine Reduce Chronic Pain After Total Knee Arthroplasty?
Lead Sponsor:
Hanyang University Seoul Hospital
Conditions:
Neuropathic Pain
Eligibility:
All Genders
50-75 years
Phase:
PHASE2
Brief Summary
Range from 24% to 44%, with a prevalence of neuropathic-type pain from 6% to 20%-cause impairment in quality of life and functional capacity after total knee arthroplasty(TKA). Duloxetine (cymbalta) i...
Detailed Description
Both groups of participants will receive pain control regimens as follows: Preemptive analgesia : celebrex celecoxib, Patient controlled analgesia (postoperation 28 hours), During admission : celebre...
Eligibility Criteria
Inclusion
- Osteoarthritis of knee requiring TKA
Exclusion
- Rheumatoid arthritis
- Other inflammatory arthritis
- Neuropsychiatric patients
- Hepatic insufficiency
- Renal insufficiency
- Patients older than 75
- Allergy or intolerance to study medications
- Patients with an ASA of IV (angina, congestive heart failure, dementia, cerebrovascular accident)
- Chronic gabapentin or pregabalin use (regular use for longer than 3 months)
- Chronic opioid use (taking opioids for longer than 3 months)
Key Trial Info
Start Date :
August 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2016
Estimated Enrollment :
168 Patients enrolled
Trial Details
Trial ID
NCT02307305
Start Date
August 1 2014
End Date
December 1 2016
Last Update
February 19 2016
Active Locations (1)
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1
Department of Orthopaedic Surgery, Hanyang University, College of Medicine
Seoul, South Korea, 133-792