Status:
WITHDRAWN
Pancreatic Cancer Screening of High-Risk Individuals in Arkansas
Lead Sponsor:
University of Arkansas
Conditions:
Pancreatic Neoplasms
Peutz-Jegher's Syndrome
Eligibility:
All Genders
18-99 years
Phase:
NA
Brief Summary
100 subjects who have a family history of pancreatic cancer (PC), or known genetic syndromes associated with increased risk of pancreatic cancer, will be followed for five years. This data will be use...
Eligibility Criteria
Inclusion
- Have a family history of PC as listed below or who have one of the following syndromes: Peutz-Jeghers syndrome - STK11; BRCA 1 and 2; PALB2; ATM; FAMMM / P16; HNPCC (Lynch) / MMR genes; Hereditary pancreatitis - PRSS1
- Individuals with three or more affected blood relatives (1st, 2nd or 3rd degree)
- Individuals with two or more affected blood relatives with PC, with at least one affected FDR, should be considered for screening.
- Patients with a history of Peutz-Jeghers syndrome should be screened, regardless of family history of PC.
- Patients with a known p16 (FAMMM syndrome) with one affected 1st or 2nd degree relative will be considered for screening.
- Patients with a known BRCA1 or BRCA2 mutation with one affected 1st or 2nd degree relative should be considered for screening.
- Patients with a known PALB2 mutation with one affected family member should be considered for screening.
- Patients with a known Mismatch-repair gene-mutation carriers (Lynch syndrome) with one affected family member should be considered for screening.
Exclusion
- Not candidates for surgery
Key Trial Info
Start Date :
November 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 19 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02309632
Start Date
November 1 2015
End Date
July 19 2019
Last Update
July 29 2019
Active Locations (1)
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1
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205