Status:
WITHDRAWN
Delayed Renal Allograft Function and Furosemide Treatment
Lead Sponsor:
Loma Linda University
Conditions:
Delayed Graft Function
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
This study will be a randomized prospective double-blind placebo-controlled clinical pilot trial. This will be a single center project that will take place at Loma Linda University Medical Center. All...
Detailed Description
1. Background/ Rationale Kidney Transplantation is a lifesaving modality in patients with end-stage renal disease (ESRD), and the numbers of transplants have been skyrocketing since the first successf...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Patient with ESRD who has been on RRT (Hemodialysis or Peritoneal dialysis)
- Recipient of deceased donor kidney transplant
- Urine output less than 0.5 mL/kg/h before transplant
- Patient consents to the study
- Patient is not allergic to furosemide or sulfa
- English or Spanish speaking patient
- Patient is oliguric (urine output less than 0.5mL/kg/h, as per AKIN criteria) or anuric (urine output less than 10 mL in 6 hours post-transplant or 2 mL/h) in the first 6 hours post kidney transplant
Exclusion
- Recipients of a living donor kidney transplant
- Patients who do not consent for the study
- Patients age \<18 years
- Patients who are allergic to furosemide or sulfa containing medications
- Non-oliguric patients
- Patients who require immediate dialysis within 6 hours of the transplant (before enrollment)
- Patients with renal ischemia due to vascular compromise that has been confirmed with Doppler Ultrasound right after transplant as per standard of care
- Patients who return to the operating room due to complications within 24 hours
- Simultaneous multi-organ transplant recipients
- Hypotensive patients with BP \<90/60 or MAP \<60 mmHg
- Patients who are on vasopressors at any time during study period
- Non-English or Spanish speaking patient
Key Trial Info
Start Date :
September 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
October 1 2016
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT02312115
Start Date
September 1 2016
End Date
October 1 2016
Last Update
November 25 2016
Active Locations (1)
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1
Loma Linda University Medical Center
Loma Linda, California, United States, 92354