Status:
UNKNOWN
Effect of Expression of CD74 and VEGF on Outcome of Treatment in Patients With Malignant Pleural Mesothelioma
Lead Sponsor:
Ain Shams University
Conditions:
Malignant Pleural Mesothelioma
Eligibility:
All Genders
19-70 years
Brief Summary
This is a prospective study evaluating the effect of expression of CD74 and VEGF on outcome of treatment in patients with malignant pleural mesothelioma receiving Pemetrexed/Platinum protocol. The par...
Eligibility Criteria
Inclusion
- Histologic or cytologic diagnosis of malignant pleural Mesothelioma
- No prior chemotherapy.
- ECOG less than or equal to 2 .
- Measurable disease according to the requirements of SWOG criteria.
- Age ≥ 19 years .
- Estimated life expectancy of at least 12 weeks .
- Adequate bone marrow reserve (white blood cells \[WBC\] ≥ 3.5 × 109 /L, neutrophils ≥ 1.5 × 109 /L, platelets ≥ 100 × 109 /L, and hemoglobin ≥ 9.0 gm/dL).
Exclusion
- Presence of central nervous system metastases.
- Inadequate liver function (bilirubin \> 1.5 times upper normal limit \[UNL\] and alanine transaminase \[ALT\] or aspartate transaminase \[AST\] \> 3.0 UNL or up to 5.0 UNL in the presence of hepatic metastases).
- Inadequate renal function (creatinine \> 1.25 times UNL, creatinine clearance \< 50mL/min).
- Serious concomitant systemic disorder incompatible with the study.
- Second primary malignancy (except in situ carcinoma of the cervix, adequately treated basal cell carcinoma of the skin, T1 vocal cord cancer in remission, or prior malignancy treated more than 5 years prior to enrollment without recurrence).
- Pregnancy
Key Trial Info
Start Date :
July 30 2019
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
July 30 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT02761863
Start Date
July 30 2019
End Date
July 30 2021
Last Update
February 23 2018
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